The range between the ED50 and TD50 can be considerable, depending on the medication. Patients who take medications at low doses may not experience benefits, while patients who take medications at higher doses could be at risk of severe complications or death. ![]() ![]() It is expressed as the range between the median effective dose, known as ED50, and the median toxic dose, TD50. The therapeutic index is the range of doses at which a medication appeared to be effective in clinical trials for a median of participants. It is important to follow directions given with such medications carefully, as a small mistake could be fatal. Care providers use caution when working with drugs that have a narrow therapeutic index to reduce risks for patients. This means that very small dosing changes could have a severe impact on outcomes for the patient. ![]() A narrow therapeutic index is a very small range of doses at which a medication provides benefits without causing severe and potentially fatal complications.
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